Thorne - Methyl-Guard Plus

Name: Thorne - Methyl-Guard Plus
Brand: Thorne
SKU: ThorneSF789
Price: 62.0 USD
Availability: InStock

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Thorne - Methyl-Guard Plus

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What Customers Say About Living.Fit

Nothing is more important than the service our customers receive. The reviews on this page are reviews from customers about their experience with ordering from Living.Fit across products from our entire catalogue.

Living.Fit is a curated fitness marketplace built for people who want quality, not clutter.

Every product on Living.Fit is selected on purpose, from verified brands we trust, with real reviews and a proven track record. No knockoffs. No copycat products. No low-quality gear competing for your attention.

Instead of endless scrolling, we focus on guidance. Clear recommendations, helpful content, and practical education to help you choose the right equipment the first time and use it with confidence once it arrives.

Living.Fit is for people who care about what they buy and how they train. Fewer products, better decisions, and a shopping experience designed to respect your time.

Easy to work with and able to ship to my home when their competitors were not

Easy to work with and able to ship to my home when their competitors were not.

Glad we could get it to you when others couldn't. Thanks for the review

Easy to order online

Easy to order online.

Great customer service

Excellent!!

Easy to order & quick to ship

Easy to order & quick to ship

Puzzling online shopping experience

1. After placing the order I was expecting a confirmation but No! Nothing! Weird! Suspicious!
2. Getting back on their website the cart was not updated and it showed differently multiple times and finally the cart was empty.
3. Why I visited the website multiple times? There's No responses from the Live Chat at all even nothing the next day. Isn't it ironic? So I started to decide the order cancellation based on 1 & 2.
3. No responses for the previous messages or processing the cancellation.
And the transaction is pending through the coming Monday. Otherwise no signs of updates on the order from them.

We’re sorry to hear about your experience and understand why this was frustrating.

Order confirmations are sent automatically immediately after an order is placed, and we have not received reports of this issue from other customers. We recommend checking your spam or promotions folder, and also confirming that there wasn't a typo in the email address entered at checkout, as either of these can prevent the confirmation from being received.

Regarding the lack of response, yesterday was a federal holiday in observance of Independence Day, so our team was out of the office. We apologize for the delay and appreciate your patience. Please rest assured that taking care of our customers is our highest priority, as reflected in the thousands of 5-star reviews we've earned. Our team will be following up with you shortly to address your concerns and ensure everything is resolved.

Thank you for bringing this to our attention, and we appreciate the opportunity to make this right.

UPDATE: We have reached out a few times after the holiday. We have not heard back from you and the order shows it was delivered within a couple days of ordering. If there is anything else you need from us, please feel free to respond to our emails.

Easy purchase process

Easy purchase process, reasonable delivery and quality prodiy

Thank you Vanessa! We appreciate the kind words

Love my new gym floors

Love my new gym floors. They are very sturdy and work amazing to keep me from sliding around. Delivery was quick.

Love seeing the setup! Glad they're doing their job and that everything arrived quickly. Thanks for the review!

The staff at Living Fit are amazing to deal with

The staff at Living Fit are amazing to deal with. They have helped me with some workout ideas

We appreciate it Brian! That means a lot to our team. We're always here to help

easy ordering and fast delivery

easy ordering and fast delivery.

We appreciate it Mike!

Great service for my new MVRK rucking

Great service for my new MVRK rucking vest!

best workout gloves around!!!!!!!!!!!!

best gloves

Great customer service!

Great customer service and great flooring

Thanks for your review of our store!

Good customer service

Good customer service.

Thanks for your purchase and for sharing! Tag us on social media as @living.fit, we love to reshare!

Should be able to edit your purchase and delivery information on the site.

Good customer response when I mentioned that I submitted the wrong address for delivery, however, after I was told my address was corrected, it did not change on the site and it went to the incorrect address.
You should be able to edit your purchase and delivery information on your site.

UPDATE November 30, 2025. We have implemented an easy way for customers to edit their address for up to two hours after an order is placed. This can be done from the post purchase email you receive, the Order Confirmation page or when you login to your Order History: https://account.living.fit/orders

ORIGINAL REPLY
Thank you for taking the time to share your feedback. We really appreciate it, and I want to clarify what happened with your address change so you know exactly where things went wrong.

When you reached out, our team let you know that we would do our best to update the address. Because this item ships directly from one of our third-party partners, we are not able to edit the order ourselves once it enters their system. In this case, the vendor shipped the package very quickly, which meant the address could not be updated in time even though we tried to intervene before it went out.

We understand how frustrating this is, and we are reviewing how we communicate these situations so expectations are clearer moving forward. We are also exploring better ways to allow address updates when possible, although this can vary based on the vendor.

If there is anything else we can do to help with this order, please let us know. We want to make it right.

Shopping was easy and straight forward

Shopping was easy and straight forward. Discounts auto applied and everything was hassle free!

We appreciate you Wesley!

Back to life

Great item to have. Makes a big difference in my life . Where were you guys years ago? I Love it. I’m a lifetime customer

High Quality Equipment

High Quality Equipment

great tp work with!

its so easy to work with Living.Fit, easy site navigation and prompt service

Excellent customer service. ...

Excellent customer service. Ordered 2 sets of resistance bands, they only sent one. A simple email and they fixed it without question.

One stop shop!!!!

The site is my one stop shop for everything involving fitness. Easy to navigate and user friendly.

Lots of good programs offered

Lots of good programs to choose from! I had to narrow down the selections to one, but may be back for others!

Great, affordable

Quick delivery and lots of great content

Don't think twice give it a try and be amazed

Great place to shop for quality product with a great deal.

good customer service

Good customer service when there was issues with the dumbbells.

A Great Store to Purchase Gym Gear

Living.Fit offers very high-quality yet reasonably priced gym equipment. I'm very pleased with my purchase of a barbell from the shop. The item shipped quickly and was delivered without any issues. I also enjoy Living.Fit's humorous emails!

$62.00

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$62.00

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Overview

Various conditions and stressors can have an adverse impact on the body's methylation cycle. Nutrient deficiencies, environmental exposures, and other aspects of a modern lifestyle can cause inefficient methylation. In addition, approximately 60 percent of U.S. adults have a genetic variation that makes it difficult for their methylation cycle to function optimally. Thorne's Methyl-Guard Plus features betaine (trimethylglycine), methylated vitamin B12 (methylcobalamin) and folate (5-MTHF), as well as the active forms of vitamins B2 and B6, for providing efficient nutritional support for the body's methylation challenges.*

Benefits

MTHFR Support: Nutritional support for individuals who have MTHFR gene variations.*
Energy & Fatigue: Enhanced cellular energy production fights occasional fatigue.*
Homocysteine & Cardiovascular: Helps maintain a healthy homocysteine level in the blood, which supports cardiovascular, cognitive, and bone health.*
Fat Metabolism: Promotes fat metabolism and lean body composition.*
Neurotransmitter Production: Supports neurotransmitter production — natural chemicals that play an important role in attention, focus, mood, and sleep.*
Liver Detoxification: Promotes liver detoxification of many substances, including hormones like estrogen.*

Why Methylation Matters

Cardiovascular health.
Cellular energy production.
Fat metabolism.
Neurological function.
DNA production.
Liver detoxification processes.
Eye health.
Histamine balance.

Features

Betaine (TMG): Betaine, also known as trimethylglycine, is a superior methyl donor.
Methylated B12 & Folate: Methylcobalamin and 5-MTHF benefit individuals with certain gene mutations.*
Active B2 & B6: Key cofactors in methylation processes.
Fewer Capsules: Robust methylation support in fewer capsules per day than Thorne's original Methyl-Guard.
Third-Party Tested: Verified against label claims, confirmed free of unsafe levels of contaminants.

Who Can Benefit

Individuals with variations to MTHFR and other genes that adversely affect methylation.*
Aging individuals wanting to support cardiovascular, cognitive, and metabolic health.*
Women seeking support for estrogen metabolism and bone health.*
Individuals wanting nutritional support for fat metabolism and healthy body composition.*
Anyone with limited consumption of methylation-supportive foods like green leafy vegetables, legumes, and cruciferous vegetables.

How to Use

Suggested Use: Take 1–3 capsules daily or as recommended by your health-care practitioner.

Warnings

Allergy: This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
Pregnancy: If pregnant, consult your health-care practitioner before using this product.
Methotrexate Interaction: 5-MTHF supplementation is not recommended concurrent with methotrexate cancer therapy. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.

Various conditions and stressors can have an adverse impact on the body's methylation cycle. Nutrient deficiencies, environmental exposures, and other aspects of a modern lifestyle can cause inefficient methylation. Approximately 60 percent of U.S. adults have a genetic variation that makes it difficult for their methylation cycle to function optimally. Thorne's Methyl-Guard Plus features betaine (trimethylglycine), methylated vitamin B12 (methylcobalamin) and folate (5-MTHF), plus the active forms of vitamins B2 and B6, for efficient nutritional support of the body's methylation challenges. Third-party tested and certified.

Key features of Thorne Methyl-Guard Plus include:
• Nutritional support for individuals with MTHFR gene variations*
• Enhanced cellular energy production fights occasional fatigue*
• Helps maintain healthy homocysteine levels, supporting cardiovascular, cognitive, and bone health*
• Promotes fat metabolism and lean body composition*
• Supports neurotransmitter production for attention, focus, mood, and sleep*
• Promotes liver detoxification, including estrogen metabolism*
• Betaine (TMG) — superior methyl donor
• Robust methylation support in fewer capsules per day than original Methyl-Guard

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Q: What are the benefits of Methyl-Guard Plus?
A: Nutritional support for individuals with MTHFR gene variations; enhanced cellular energy production fights fatigue; helps maintain healthy homocysteine levels supporting cardiovascular, cognitive, and bone health; promotes fat metabolism and lean body composition; supports neurotransmitter production for attention, focus, mood, and sleep; and promotes liver detoxification including estrogen metabolism.

Q: How does it help with MTHFR gene variations?
A: Methyl-Guard Plus features betaine (trimethylglycine), methylated vitamin B12 (methylcobalamin) and folate (5-MTHF), plus the active forms of vitamins B2 and B6, for efficient nutritional support for individuals with MTHFR gene variations.

Q: What is betaine (TMG)?
A: Betaine, also known as trimethylglycine (TMG), is a superior methyl donor. Along with methylated B12 and folate, it helps recycle homocysteine to the amino acid methionine.

Q: Why is methylation important?
A: Methylation significantly impacts many biochemical reactions and plays a beneficial role in cardiovascular health, cellular energy production, fat metabolism, neurological function, DNA production, liver detoxification, eye health, and histamine balance.

Q: How should I take Methyl-Guard Plus?
A: Take 1–3 capsules daily or as recommended by your health-care practitioner.

All purchases accumulate points which be can used to redeem for discounts on all items in our rewards collection. Enroll or view your current rewards balance here.

Earn 40 points for every $1 spent equaling 5% cash back

DESCRIPTION

Various conditions and stressors can have an adverse impact on the body's methylation cycle. Nutrient deficiencies, environmental exposures, and other aspects of a modern lifestyle can cause inefficient methylation. Approximately 60 percent of U.S. adults have a genetic variation that makes it difficult for their methylation cycle to function optimally. Thorne's Methyl-Guard Plus features betaine (trimethylglycine), methylated vitamin B12 (methylcobalamin) and folate (5-MTHF), plus the active forms of vitamins B2 and B6, for efficient nutritional support of the body's methylation challenges. Third-party tested and certified.

Key features of Thorne Methyl-Guard Plus include:
• Nutritional support for individuals with MTHFR gene variations*
• Enhanced cellular energy production fights occasional fatigue*
• Helps maintain healthy homocysteine levels, supporting cardiovascular, cognitive, and bone health*
• Promotes fat metabolism and lean body composition*
• Supports neurotransmitter production for attention, focus, mood, and sleep*
• Promotes liver detoxification, including estrogen metabolism*
• Betaine (TMG) — superior methyl donor
• Robust methylation support in fewer capsules per day than original Methyl-Guard

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FAQ

Q: What are the benefits of Methyl-Guard Plus?
A: Nutritional support for individuals with MTHFR gene variations; enhanced cellular energy production fights fatigue; helps maintain healthy homocysteine levels supporting cardiovascular, cognitive, and bone health; promotes fat metabolism and lean body composition; supports neurotransmitter production for attention, focus, mood, and sleep; and promotes liver detoxification including estrogen metabolism.

Q: How does it help with MTHFR gene variations?
A: Methyl-Guard Plus features betaine (trimethylglycine), methylated vitamin B12 (methylcobalamin) and folate (5-MTHF), plus the active forms of vitamins B2 and B6, for efficient nutritional support for individuals with MTHFR gene variations.

Q: What is betaine (TMG)?
A: Betaine, also known as trimethylglycine (TMG), is a superior methyl donor. Along with methylated B12 and folate, it helps recycle homocysteine to the amino acid methionine.

Q: Why is methylation important?
A: Methylation significantly impacts many biochemical reactions and plays a beneficial role in cardiovascular health, cellular energy production, fat metabolism, neurological function, DNA production, liver detoxification, eye health, and histamine balance.

Q: How should I take Methyl-Guard Plus?
A: Take 1–3 capsules daily or as recommended by your health-care practitioner.

EARN REWARDS

All purchases accumulate points which be can used to redeem for discounts on all items in our rewards collection. Enroll or view your current rewards balance here.

Earn 40 points for every $1 spent equaling 5% cash back

Thorne - Methyl-Guard Plus

Thorne - Methyl-Guard Plus